Pain in the ball of the foot, also called metatarsalgia is caused by chronic weight and pressure on the bottom of the ball of the foot area. This pressure causes pain and discomfort. Women who wear high heels as well as athletes and runners are most susceptible to this condition. The normal fat pads that we have under the ball of the foot can become inflamed, atrophied and sore. With time as we age these natural pads do wear out as well. High heels and the extra pressure on the ball of the feet can push these natural fat pads out of position also, and the proper cushioning system of the foot is compromised. This condition can be quite painful, debilitating and chronic.